World number one Dustin Johnson will tee off at 8:48 CT, alongside four-time major winner Rory McIlroy and former Masters champion Charl Schwartzel.
Jordan Spieth hits the course at 3:47 with 2016 Open champ Henrik Stenson and Si-Woo Kim. Spieth finished tied for 30th at last year's Open Championship.
After missing the U.S. Open at Erin Hills for his daughter's high school graduation, Phil Mickelson returns to major championship action at 9:10 a.m. Erin Hills victor Brooks Koepka hits the course at 4:09 a.m. with golf's second-ranked golfer Hideki Matsuyama and Tommy Fleetwood.
There will also be some Wisconsin flavor throughout this tournament. Madison native Steve Stricker tees off at 1:41 a.m. Stricker, 50, finished fourth at Royal Troon last year, his best Open result of his career.
Royal Birkdale has hosted the Open Championship nine times. Padraig Harrington took home the Claret Jug in 2008, which was the last time the tournament was located at the Manchester area course.