Shaw was initially hurt after he fouled a ball of his foot during his first at-bat of the night that ended in a strikeout.
Hernan Perez replaced him defensively at third base during the next half inning.
With Ryan Braun in the lineup tonight, Brewers fans had to feel like the team was finally getting healthy again, but Shaw's exit adds to the rash of injuries that's plagued the NL central division leading club thus far.
Braun, Christian Yelich, Lorenzo Cain, Eric Thames, Jimmy Nelson, Corey Knebel, Boone Logan and Wade Miley have all missed at least a stretch with some ailment.
Following his impressive 2017 campaign, Shaw got off to a slower start in 2018.
Through 111 at-bats, he's accumulated a .243 average, .811 OPS, 6 home runs, and 16 RBI. Certainly not bad, but not stand out. Though, he has improved his strikeout to watch ratio. He's walked 15 times and only struck out 24 times.