SAN DIEGO (AP) -- Orlando Arcia singled in Ji-Man Choi with two outs in the 12th inning to lift the Milwaukee Brewers over the San Diego Padres 2-1 on opening day Thursday.
Arcia's hit came off sidearmer Adam Cimber (0-1), who was making his big league debut. After getting Manny Pina to hit into a double play, Cimber allowed Choi's pinch-hit double before Arcia's go-ahead RBI.
Jeremy Jeffress (1-0) pitched two innings for the win. Jacob Barnes struck out the side in the 12th for the save.
The Padres had the bases loaded with one out in the 11th, with newcomer Eric Hosmer poised to score the winning run, but Chase Headley, back with San Diego after 3 1/2 seasons with the New York Yankees, grounded into a double play.
The Brewers were one out away from winning 1-0 on a four-hitter when Freddy Galvis, acquired in a trade with Philadelphia, singled to right off Corey Knebel, a first-time All-Star last year, to bring in Carlos Asuaje and send it into extra innings. Asuaje singled with one out and stole second with two outs.
Milwaukee's Chase Anderson allowed one hit in six innings in his first opening day start. He had six strikeouts and three walks.
The right-hander also singled to center off Clayton Richard with two outs in the third, advanced on Lorenzo Cain's single to left and scored on Christian Yelich's single to left. A late, awkward slide left the pitcher shaken up momentarily, but he stayed in the game.
Richard, making his first opening day start at age 34, went seven innings, allowing one run and six hits with four strikeouts and one walk.
The Padres flashed some nice defense. Galvis, San Diego's fifth different starting shortstop in five opening days, made a terrific play in the second when he fielded Pina's hard one-hopper as he went to the ground and flipped the ball to second baseman Asuaje to start an inning-ending double play. Headley, the third baseman, made a nice play on Ryan Braun's hard grounder to start an inning-ending double play in the first.
Hosmer, signed to a $144 million, eight-year contract early in spring training, went 0 for 4 with a walk and two strikeouts in his Padres debut.
Trevor Hoffman, who will be inducted into the Hall of Fame in July, threw the ceremonial first pitch to his older brother, Glenn, the Padres' third base coach. Trevor Hoffman played the bulk of his career with the Padres before playing two seasons with Milwaukee.
Before the national anthem, the Padres held a moment of silence for three former members of the organization who died in recent months: Kevin Towers, Dick Enberg and Rob Picciolo. Towers was general manager for 14 years, building four division winners, including the 1998 team that went to the World Series. Enberg finished his long Hall of Fame career with seven seasons as the Padres TV voice. Picciolo was a longtime coach.
LHP Joey Lucchesi is scheduled to make his big league debut for the Padres on Friday night after recording a 1.54 ERA in four spring starts. The Brewers will counter with RHP Jhoulys Chacin, who went 13-10 with a 3.89 ERA with San Diego last season.