Milwaukee police were called to the area of N. 5th Street and W. North Ave. just before 8:00 a.m. Saturday.
According to police, a 44-year-old woman sustained life-threatening injuries from the shooting.
She was taken to a local hospital for treatment and police are looking for an unknown suspect.
If you have any information you are asked to call Milwaukee police at 414-935-7360 or Crime Stoppers at 414-224-TIPS.